A STUDY ON ETHOSOMES AS MODE FOR TRANSDERMAL DELIVERY OF ANANTIPSORIATIC DRUG

Abstract

The aim of the present research work is to prepare ethosome of Berberine chloride and to
evaluate for vesicle shape, size, polydispersity index (PDI), zeta potential (ZP), entrapment
efficiency (EE), and in vitro permeation studies. Berberine Chloride loaded nanosized ethosomes
were prepared using hot method with varied concentrations of ethanol and
soyaphosphotidylcholine (SPC). The prepared ethosomes were characterized by size, entrapment
efficiency (EE), FT-IR, in vitro release, kinetic studies of in vitro release profile and stability
study. The selected ethosomal formulation was incorporated in carbapol 934P for gel formation,
and subsequently, evaluated for their physicochemical properties. The sizes of ethosomes were
found to be in the range of 94. 07-297.11nm while PDI ranges from 0.261 to 1.53 and ZP was
between −20.6 to−40.1 mV. Morphology studies showed unilamellar structure under
transmission electron microscope and optical microscopy. The EE of ethosomes was found to be
in the range of 42.5% to 90.01%. It may be concluded that a Berberine chloride loaded
ethosomal delivery system for herbal medications is a promising technique.